Study by Han and colleagues. Overexpression of SHANK3 resulted in an unanticipated phenotype consisting of seizures and hyperactivity. On a cellular level, the balance between excitatory and inhibitory synapses was shifted towards excitation, suggesting that SHANK3 levels serve as a molecular regulator for the level of excitation versus inhibition.
Child Neurology Fellow and epilepsy genetics researcher at the Children’s Hospital of Philadelphia (CHOP), USA and Department of Neuropediatrics, Kiel, Germany
