SLC25A22 is a glutamate transporter across the inner mitochondrial membrane. Recessive mutations in the SLC25A22 gene may result in familial malignant migrating seizures of infancy (MPSI/MMPSI) or neonatal epileptic encephalopathy with suppression burst pattern (NEEB). Both phenotypes are catastrophic epilepsies of infancy, but are clearly distinct.

Ingo Helbig

Child Neurology Fellow and epilepsy genetics researcher at the Children’s Hospital of Philadelphia (CHOP), USA and Department of Neuropediatrics, Kiel, Germany

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