Silencing of miR-134 reduces pathological features of epilepsy

(a–f) In vivo studies showing how silencing of miR-134 protects against status epilepticus. Graphs and representative photomicrographs from the dorsal hippocampus of mice 24 h after status epilepticus in mice treated beforehand with Scr (as control) or Ant-134. Shown are the counts for three markers, Fluoro-Jade B (FJB, a marker of neuronal death; a,b), DNA fragmentation (terminal deoxynucleotidyl dUTP nick end labeling; TUNEL; c,d) and the neuronal marker NeuN (c,d). Mice injected with Ant-134 show a clear reduction in FJB and TUNEL staining and less of a loss of NeuN staining after status epilepticus, highlighting the neuroprotective effects of the antagomir. Adapted by permission from Macmillan Publishers Ltd: Nature Medicine (E. M. Jimenez-Mateos et al., Vol. 18, p. 1087–1094, 2012), copyright (2012)

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