Alternative splicing in DmNav, the Drosophila sodium channel gene. Inclusion of exon L increases the persistent (“leaky”) sodium current, which leads to hyperexcitability. However, alternative splicing with insertion of the L exon occurs in response to increased activity, leading to a self-perpetuating loop.

Ingo Helbig

Child Neurology Fellow and epilepsy genetics researcher at the Children’s Hospital of Philadelphia (CHOP), USA and Department of Neuropediatrics, Kiel, Germany

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