The power of the secondary analysis. If you work with exome data, it will be around for quite some time. With more than 2/3 of patients without mutations identified through exome sequencing, the existing data will have to be revisited from time to time. The study of Guven and Tolun demonstrates how perseverance may help finally identify a gene.
Child Neurology Fellow and epilepsy genetics researcher at the Children’s Hospital of Philadelphia (CHOP), USA and Department of Neuropediatrics, Kiel, Germany