tudy by Baraban and collaborators. Zebrafish larvae deficient in scn1Lab were found to have a peculiar behavioral swimming phenotype that could be assayed at medium throughput. Mutant animals showed an increased swim velocity, which represents behavioral seizures. This behavioral assay was used to screen 320 compounds. Only one compound (clemizole) was found to reduce the swim velocity and abolish electrographic seizures.
Child Neurology Fellow and epilepsy genetics researcher at the Children’s Hospital of Philadelphia (CHOP), USA and Department of Neuropediatrics, Kiel, Germany