This paper demonstrates that overexpression of CACNA1G using a transgenic mouse model results in spike-wave discharges and absence seizures, indicating that enhancement of T-type calcium currents is sufficient for the generation of absence seizures.
The authors demonstrate that CACNA1G mediated currents are both necessary sufficient for the generation of absence seizures. Genetic ablation of this gene actually makes mice resistent against spike-wave discharges when introduced into other mouse models.
Ingo
This 2009 blog post has been transferred to the EuroEPINOMICS blog from www.epilepsygenetics.net.
Please quote this blog (APA format) as
Helbig, I. CACNA1G overexpression induces spike-wave discharges. Retrieved [enter date], from http://www.euroepinomics.wordpress.com