BRE and association with ELP4

The genetics of Benign Rolandic Epilepsy (BRE) is complicated and now genetic variants predisposing to BRE have been discovered to date. This study now shows association of the BRE phenotype and phenotype of centrotemporal spikes (CTS) with an intronic SNP in ELP4 (Elongator Protein Complex 4) in a genome-wide linkage scan and subsequent confirmation in a small association study.


This 2009 blog post has been transferred to the EuroEPINOMICS blog from

Please quote this blog (APA format) as

Helbig, I. BRE and association with ELP4. Retrieved [enter date], from


Ingo Helbig

Child Neurology Fellow and epilepsy genetics researcher at the Children’s Hospital of Philadelphia (CHOP), USA and Department of Neuropediatrics, Kiel, Germany

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