This paper is featured since it deals with the basics of epilepsy genetics – investigating whether a phenotype has a genetic contribution by looking at familial aggregation. The authors investigate patients with neuro-cysticercosis and do not find evidence for familial aggregation.
Whereas the methodology is straightforward, it remains unclear what effect the authors could exclude. For example, one would not expect a large degree of familial aggregation in herpes simplex encephalitis, but mutations in TLR3 and UNC-93B can be identified in some patients.
Ingo
This 2009 blog post has been transferred to the EuroEPINOMICS blog from www.epilepsygenetics.net.
Please quote this blog (APA format) as
Helbig, I. The genetics of seizures in neurocysticercosis. Retrieved [enter date], from http://www.euroepinomics.wordpress.com
Child Neurology Fellow and epilepsy genetics researcher at the Children’s Hospital of Philadelphia (CHOP), USA and Department of Neuropediatrics, Kiel, Germany
